8-Jan-10 10:00 AM CST

Neuro-Tumor Club Dinner Meeting, April 19, Washington, DC

16^th Neuro-Tumor Club Dinner Meeting at AACR

Time: Monday April 19, 2010; 6:30 – 10:00pm

Location: Washington Marriott at Metro Center, 775 12th Street Northwest, Washington, DC 20005

Chairs: Russell Lonser, MD and John Park, MD, PhD

The 16th Neuro-Tumor Club Dinner Meeting took place during the AACR Annual Meeting in Washington, DC. This meeting, for brain tumor researchers attending the AACR Annual Meeting, is organized annually by the Society for Neuro-Oncology.

As in past years, this event was an informal and stimulating exchange of late-breaking findings of specific and focused interest to investigators dedicated to brain tumor research.

2010 PROGRAM

6:30-7:00 Buffet Dinner Service

7:00-7:05 Introductions and Acknowledgments

Russell Lonser and John Park, National Institutes of Health

Session 1: Stem Cells

7:05-7:10 Overview: Jeremy Rich - Cleveland Clinic

7:10-7:15 1 Jialiang Wang, Duke University

The role of Notch in radiation resistance of glioma stem cells

7:20-7:25 2 Adam S. Wu, UT M.D. Anderson Cancer Center

Glioma cancer stem cells induce immune suppressive macrophages

7:30-7:35 3 Christine Eyler, Cleveland Clinic, Duke University

Integrin a6 is a functionally significant marker of glioma stem cells

7:40-7:45 4 Candace Gilbert, University of Massachusetts Medical School

Enhanced glioma therapy with combined temozolomide and gamma-secretase inhibitor treatment

Session 2: Angiogenesis and Tumor Microenvironment

7:50-7:55 Overview: Fabio Iwamoto - National Institutes of Health

7:55-8:00 5 Dario Marchetti, Baylor College of Medicine

Heparanase modulates Shh and Wnt3a signaling in human medulloblastoma cells

8:05-8:10 6 Leslie L. Muldoon, Oregon Health & Sciences University

Vascular effects of anti-integrin antibody in a rat brain tumor model

8:15-8:20 7 Jason Pradarelli, Ohio State University

The effect of a novel angiogenesis inhibitor TM on the efficacy of oncolytic virus

8:25-8:30 8 Jayson Hardcastle, Ohio State University

Vstat120 modulates the innate pro-inflammatory response to oncolytic virus

Session 3: New Hopes for Immunotherapy in Brain Tumors

8:35-8:40 Overview: John Yu - Cedars-Sinai Medical Center

8:40-8:45 9 Maria G. Castro, UCLA Geffen School of Medicine

Blocking CTLA4 signaling enhances the anti-glioma immunotherapy mediated by combined Ad-TK/Ad-Flt3L mediated gene therapy

8:50-8:55 10 Michael Gustafson, Mayo Clinic

The role of CD14+HLA‐DRlo/neg monocytes in glioblastoma‐mediated immunosuppression

9:00-9:05 11 Allen Waziri, University of Colorado Health Sciences Center

Hypoxia-derived suppressive monocytes in GBM: a source of cellular immunosuppression

Session 4: New Tools and Translational Science

9:10-9:15 Overview: Waldemar Debinski - Wake Forest University

9:15-9:20 12 Marc Remke, German Cancer Research Center

MicroRNA expression discriminates molecular risk groups in medulloblastoma

9:25-9:30 13 Hideho Okada, University of Pittsburgh Cancer Institute

Vaccination of patients w/ low grade glioma–high magnitude of type-1 antigen specific response

9:35-9:40 14 David Solomon, Georgetown University School of Medicine

Pharmacologic inhibition of CDK4/6 arrests the growth of glioblastoma multiforme intracranial xenografts

9:45-10:00 Mingle together and more discussion

NOTE: Each talk is 5 minutes, followed by a 5 minute discussion

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For additional information on this Member News article, please contact:

Chas Haynes
(713) 526-0269

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