Multi-Disciplinary Organization Dedicated to Promoting Advances in
Neuro-Oncology Through Research and Education

WFNOS Magazine

The inaugural issue of the official publication of the World Federation of Neuro-Oncology Societies is ...

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Neuro-Oncology Review Course at SNO

November 16, 2016. Register in conjunction with the SNO Annual Meeting

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CNS Anticancer Drug Discovery and Development Conference

Register Now!

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October
12

EANO 2016

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October
22

18th Annual Brain Tumor Update and 7th Annual International Symposium on Long-Term Control of Metastases to the Brain and Spine

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November
16

2nd CNS Anticancer Drug Discovery/Development Conference

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Ohio State University

The Ohio State University Medical Center
Department of Radiation Oncology
James Comprehensive Cancer Center
Tzagournis Medical Research Facility #514B
Office: #514B; lab room: #510
420 W 12th Ave
Columbus, OH 43210
USA
 
Contact:
Deliang Guo, Ph.D.
Deliang.Guo@osumc.edu
614-366-3774
 
Research Categories:
 
   - Molecular targeted therapy and lipid metabolism in glioblastoma
 
Research Interests/projects:
 
   - Dr. Guo’s lab is focusing on EGFR/RTKs/PI3K/Akt and Ras/MEK/ERK signaling transduction and cancer metabolism. Recently
     he and colleagues uncovered EGFR/PI3K/Akt signaling upregulates SREBP-1 activity to promote de novo fatty acid synthesis
     and increase cholesterol uptake in brain tumor patients, and demonstrate SREBP-1 and its regulated key genes ACC, FAS and
     LDLR as novel molecular targets in cancer (Guo, et al, PNAS, Science Signaling, and Cancer Discovery 2009). Dr. Guo's work
     is committed to unraveling how EGFR/PI3K signaling regulates metabolism network, to unravel the link between glucose
     uptake and lipid metabolism, to identify the key molecular targets in this network and develop potent inhibitors to translate
     into clinical trial to eradicate cancer cells.