The Ohio State University Medical Center
Department of Radiation Oncology
James Comprehensive Cancer Center
Tzagournis Medical Research Facility #514B
Office: #514B; lab room: #510
420 W 12th Ave
Columbus, OH 43210
Deliang Guo, Ph.D.
- Molecular targeted therapy and lipid metabolism in glioblastoma
- Dr. Guo’s lab is focusing on EGFR/RTKs/PI3K/Akt and Ras/MEK/ERK signaling transduction and cancer metabolism. Recently
he and colleagues uncovered EGFR/PI3K/Akt signaling upregulates SREBP-1 activity to promote de novo fatty acid synthesis
and increase cholesterol uptake in brain tumor patients, and demonstrate SREBP-1 and its regulated key genes ACC, FAS and
LDLR as novel molecular targets in cancer (Guo, et al, PNAS, Science Signaling, and Cancer Discovery 2009). Dr. Guo's work
is committed to unraveling how EGFR/PI3K signaling regulates metabolism network, to unravel the link between glucose
uptake and lipid metabolism, to identify the key molecular targets in this network and develop potent inhibitors to translate
into clinical trial to eradicate cancer cells.