Highlighting Tutorial Sessions
Thursday, November 13, 5:30-7:00 pm
Preparing a Phase I/II Clinical Trial
Location: Cowrie 1,2
Chair: Susan M. Chang M.D. (UCSF)
Target Audience: Residents, fellows, nurses, and junior faculty interested in developing phase I or II trials in neuro-oncology.
The clinical trials session will provide information on the how to design high quality phase I and II trials in neuro-oncology. There will be a focus on the critical issues and pitfalls in designing these studies.
- Design of Phase I Trials
Susan M. Chang MD
- Design of Phase II Trials
Martin Van Den Bent, MD
- Statistical Issues in Trial Design
Karla Ballman, PhD
Friday, November 14, Noon-1:30 pm
Imaging Standardization Symposium
Location: The James Hotel –Great Room
The Imaging Standardization Symposium will focus on the role of standardization and quantitative analysis of imaging acquired for brain tumor drug trials. Speakers from the National Cancer Institute’s Quantitative Imaging Network will provide updates on the program’s promotion of “research and development of quantitative imaging methods for the measurement of tumor response to therapies in clinical trial settings” with the ultimate goal of facilitating clinical decision making. The potential for implementing standardized imaging protocols developed in conjunction with the National Brain Tumor Society/Food and Drug Administration/National Cancer Institute’s steering committee will be addressed. Lastly, an update on the American College of Radiology Imaging Network’s role in the conduction of multicenter drug trials will be provided. The Symposium will conclude with a short question and answer session with audience participation.
NCI’s Quantitative Imaging Network
- Introduction: Current role of neuroimaging in managing brain tumor patients from the Neuro-Oncologists’ perspective.
Matthias Holdhoff, MD
- What is the purpose and current status of NCI’s Quantitative Imaging Network (QIN)?
Robert Nordstrom, PhD
- NCI-funded QIN Projects that are relevant to the Neuro-Oncology community
Hyunsuk Shim, PhD
NBTS/FDA/NCI Steering Committee for the Brain Tumor Imaging Standardization
- NBTS/FDA/NCI Steering Committee for the Standardization of Imaging in Neuro-Oncology - Current Recommendations & Future Goals
Ben Ellingson, PhD
ACRIN: American College of Radiology Imaging Network
- Multicenter Imaging Trials in Neuro-Oncology: ACRIN update
Dan Barboriak, MD
Friday, Nov 14, Noon-1:30 pm
Copy Number Variation
Chair: Rameen Beroukhim
This is a new session being introduced for the first time at this meeting. As it is an interactive session, space will be limited to approximately 20-30 attendees. It will be on a first come first serve basis. Depending on the feedback we receive on this session we will intend to expand for future meetings.
We will discuss challenges to the detection and interpretation of somatic copy-number alterations in cancer, including:
- Technical and biologic artifacts contributing to the false positive and negative results
- Distinguishing between driver and passenger alterations
- Identifying genes that may account for the driver alterations
- Issues that arise in the genotyping of individual tumors with respect to driver copy-number alterations
- Interpretation of positive and negative correlations between genetic events and other features of the cancers
Saturday, November 15, Noon-1:30 pm
CSNO Lunchtime Session
Chair: Zhong-ping Chen
This meeting will focus on developing strategies to improve the training of academic neuro-oncologists and their ability to conduct high quality clinical trials in China and similar countries.
Target Audience: Clinicians from developing countries interested in improving their ability to conduct clinical trials
- Overview of Neuro-Oncology in China
Zhong-Ping Chen MD, PhD
- Challenges of conducting clinical trials in China
Jun-Ping Zhang, MD
- Training of neuro-oncologists in North America
Eudocia Quant Lee, MD