Multi-Disciplinary Organization Dedicated to Promoting Advances in
Neuro-Oncology Through Research and Education

SNO-SCIDOT Joint Conference on Therapeutic Delivery to the CNS

Abstract Deadline: July 10, 2017 11:59pm CST

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SNO Annual Meeting - November 16 - 19, 2017

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Brain Tumor Biorepository Established

Ian's Friends Foundation, Children's Health Care of Atlanta

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September
02

International Meeting on Meningioma

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September
07

Mayo Clinic Neuroscience and Oncology Innovation Summit 2017

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Sunrise Sessions and Lunch Tutorials

 

 

SNO/ASNO Joint Sesson: New Horizons in PET Imaging in Neuro-Oncology (ASNO/SNO)   

  • Role of amino acid-tracer PET for decision making in neuro-oncology, Joerg-Christian Tonn
  • Usefulness of positron emission tomography (PET) for CNS tumors, Keisuke Miyake
  • Feedback of the PET-imaging to the treatment of malignant brain tumors and radiation injuries, Shin-Ichi Miyatake
  • Simultaneous PET/MRI in clinical neuro-oncology, Ian Law

A "Vagabond Theory" of Glioblastoma: Picking One's Way Through the Brain Microenvironment to Fatal Progression 

  • From niche to milieu, Michael Berens
  • Macro effects of microglia and macrophages, Joanna Phillips
  • Cloak and dagger, Justin Lathia
  • Inside out - The making of the microenvironment of glioblastoma, Jakub Godlewski

Immune Based Therapies for Glioma      

  • Cellular immunotherapy targeting glioblastoma, Duane Mitchell
  • Immune checkpoint inhibitors for malignant gliomas, Michael Lim
  • Immunotherapy targeting glioma neoantigens, Hideho Okada
  • Overcoming immunosuppression in malignant gliomas, Derek Wainwright

Therapeutic Opportunities Presented by Dysregulated Cell Signaling Mechanisms

  • Uncoupling tumor heterogeneity to promote therapeutic sensitivity, Frank Furnari
  • Regulatory circuits in GBM subtypes, Shi-Yuan Cheng
  • Next-generation therapies to treat driver pathways in glioblastoma, William Weiss
  • Metabolic signaling and epigenetic regulation in glioma, Zhimin Lu

Current Update on the Diagnosis and Management of Lower Grade Gliomas        

  • Contemporary molecular classification of lower grade gliomas with implications for diagnosis and grading, Daniel Brat
  • Ancestry of multifocal lower grade gliomas, Joseph Costello
  • Title Pending, Elizabeth Maher
  • Intraoperative IDH status determining extent of resection and outcome, Gelareh Zadeh

Getting More Out of Radiation: Combination Therapy and Dose Escalation           

  • Mechanisms to improve the effect of radiation, Erik Sulman
  • Escalating the dose to improve the outcome of patients with glioblastoma, Christina Tsien
  • Multi-arm & adaptive trials to improve the efficacy of radiation, Brian Alexander
  • Blood brain barrier penetration in radio-sensitivity, Jann Sarkaria

               

SATURDAY, NOVEMBER 18

Novel Metabolic Targets and Their Genetic Basis in Glioma          

  • Metabolic profiling of glioma, Sabrina Ronen
  • Temozolomide and metabolism in IDH1 mutant glioma, Daniel Cahill
  • Lipogenesis and glioblastoma, Deliang Guo
  • Metabolic dependencies induced by IDH1 mutation, Samuel McBrayer

EANO-SNO Joint Sunrise Session: Glioblastoma in the Elderly: Solid Conclusions Built on Shifting Sand?
Wolfgang Wick, Tracy Batchelor, Co-Chairs

  • Specific Requirements of elderly patients, Roberta Rudà
  • Update on molecular biomarkers in the elderly, Jason Huse
  • Surgery in the elderly glioma patient, Colin Watts
  • Standard of care postsurgical therapy 2017, James Perry

Using Patient Reports as a Measure of Net Clinical Benefit            

  • Integrating patient report measures into neuro-oncology clinical practice: Opportunities for targeted interventions, Christina Amidei
  • Understanding the natural history of rare CNS tumors through patient self-report and web-based portals, Terri Armstrong
  • Applying patient report measures as quality metrics in pediatric brain tumor care, Jin-Shea Lai
  • Patient report measures in research, Martin Taphoorn

Histone Mutations in Pediatric Gliomas   

  • Oncohistones: Professional hijackers of the epigenome, Nada Jabado
  • The ABCs of chromatin biology and biochemical insights into the mechanisms of histone mutations, Peter Lewis
  • Diagnostic and prognostic implications of histone mutations in clinical practice, Cynthia Hawkins
  • Targeting histone mutations in the clinic, are we there yet?, Oren Becher

Brain Metastases            

  • Microenvironmental interactions in brain metastasis, Adrienne Boire
  • Brain metastasis genomics, Priscilla Brastianos
  • Targeted therapy in brain metastasis, Manmeet Ahluwalia
  • Brain metastasis-microenvironment interactions: an emerging source of innovative therapies, Manuel Valiente

Tumor-related Epilepsy 

  • EEG monitoring and brain mapping in TRE, Jeffrey Politsky
  • Epidemiology and etiology of TRE, Joon Uhm
  • Medical/pharmacologic considerations in TRE, Patrick Wen
  • Systems biology and surgical treatment of TRE, Sandeep Mittal

 

SUNDAY, NOVEMBER 19

Circulating Biomarkers  -Technology and Application       

  • Biomarkers and effectors of the cellular interactome in cancer, Janusz Rak
  • Glioblastoma transgenic mouse models for advance in biomarker studies, Alain Charest
  • Immune evasion mediated by PD-L1 on glioblastoma-derived exosomes, Sean Lawler
  • Heterogeneity of EVs cargo in the progression and therapeutic response in glioblastoma, Agnieszka Bronisz

Clonal Evolution of Glioblastoma              

  • Clonal evolution and prediction of pharmacologic vulnerabilities of human glioma, Antonio Iavarone
  • Deciphering single-cell programs in adult and pediatric gliomas, Mario Suva
  • Deconstructing clonal composition in glioma through multiomic analysis of serial sections, Michael Oldham
  • Integrated model of clonal evolution, Joseph Costello

Viral Therapy: Advances from Bench to Bedside 

  • Determining the optimal dose for phase II/III studies of OV: the lesson of poliovirus, John Sampson
  • Oncolytic adenoviral therapy for glioma and use of adjuvant treatments, Frederick Lang
  • Toca-511 trials and implications of survival-related mRNA expression profiles in OV trials for glioma, Noriyuki Kasahara
  • Oncolytic HSV for glioma-potential for childhood cancers and use of immunogene therapy, James Markert

Discovery, Characterization and Functionalizing Novel Glioma Genes        

  • Overview of Glioma Epidemiologic Studies, Melissa Bondy
  • Identification of germline mutations in glioma families identified through whole genome sequencing, Matthew Bainbridge
  • Identification of novel SNPS identified through GWAS analysis, Margaret Wrensch
  • Developing the pipeline using CRISPR to functionalize genes identified through genetic screening, Benjamin Deneen

Meningiomas: Molecular Advances Toward Developing Targeted Therapies          

  • Methylation classifier for meningiomas: beyond WHO grading, Kenneth Aldape
  • Lessons learned from genomic landscape of atypical meningiomas, Ian Dunn
  • RNA pathway analysis directing therapeutic strategies in meningiomas, Gelareh Zadeh
  • Challenges and opportunities in clinical trials for meningiomas, Michael Jenkinson

Developing Cancer Stem Cell Targeting Strategies             

  • Attenuating cell-cell communication in CSCs via drug repurposing strategies, Justin Lathia
  • Targeting neurotransmission to compromise self-renewal, Peter Dirks
  • Sexual dimorphism in CSC drug responses, Joshua Rubin
  • Using pluripotent stem cells to model CSCs and identify novel drug targets, Viviane Tabar

                                                                          

 

LUNCH SESSIONS
12:15pm – 1:15pm

 

FRIDAY, NOVEMBER 17

Epigenetics of CNS malignancies

  • Defining the non-coding epigenome of glioma CpG Island Methylator Phenotype (G-CIMP), Houtan Noushmehr
  • Disentangling developmental and oncogenic epigenetic states of medulloblastoma subtypes, Paul Northcott
  • Histone modifications in pediatric brain tumors, Sriram Venneti

Palliative Care - Health Outcome Measures and Communication Strategies in Neuro-Oncology

  • Introduction to palliative care in neuro-oncology and health outcome measures, Tobias Walbert
  • Communication strategies in neuro-oncology, Alan Carver
  • Palliative care integration into neuro-oncology, Jennifer Philip

Emerging Functional and Genomic Single Cell Technologies

  • Single cell mass as a novel biomarker of drug response in brain tumors, Keith Ligon
  • Single cell cloning analysis of tumors and their treatment hierarchies using optical bar coding, Katrin Lamszus
  • EvoSeq: A molecular time machine to characterize resistance at a single cell level, Pratiti Bandopadhayay

Clinical Trials - A Primer for Junior Investigators

  • Design of phase 0 and I trials, Patrick Wen
  • Phase II Trials, Timothy Cloughesy
  • Basic statistics for clinical trials, Karla Ballman

  

SATURDAY, NOVEMBER 18                       

Introduction to CRISPR-based Technologies         

  • CRISPRi and CRISPRa for programmable transcriptional control, Daniel Lim
  • Opportunities and challenges of CRISPR-Cas gene editing, Jennifer Doudna
  • CRISPR/Cas9 for genome editing, Alex Marson

Basic Science in Neuro-Oncology for the Clinician             

  • Biology of primary brain tumors – The basics, Vinay Puduvalli
  • Basic immunology for the clinician, Amy Heimberger
  • Genomics and Epigenomics in neuro-oncology: making sense of the maze, Russell Pieper

Quantitative Biology in Neuro-Oncology

  • Public portal pearls and pitfalls: a hitchhiker’s guide to available data and analysis resources, Cameron Brennan
  • Large scale systems biology in brain cancer genomics, Michele Ceccarelli
  • Functional characterization of glioma cancer genes, Antonio Iavarone

Surgical Trials: From Design to Regulatory Approval         

  • Clinical trial design for neurosurgeons, Michael Vogelbaum
  • Getting FDA approval for devices and diagnostic tools (5-ALA), Constantinos Hadjipanayis
  • Phase 0 clinical trials and associated opportunities for neurosurgeons, Nader Sanai