MICHELLE MONJE, MD, PHD
Dr. Monje is Associate Professor of Neurology and, by courtesy, of Neurosurgery, of Pediatrics, of Pathology and of Psychiatry and Behavioral Sciences at Stanford University.
Honors & Awards
Young Investigator Award, Hagerty Foundation for Glioma Research (2006)
K08 Mentored Clinical Scientist Career Development Award, National Institutes of Neurological Disorders and Stroke (2010 - 2015)
Peter A. Steck Memorial Award, Pediatric Brain Tumor Foundation (2011)
Basic Science IV Award, California Institute of Regenerative Medicine (CIRM) (2012 - 2015)
‘A’ Award, Alex’s Lemonade Stand Foundation (2012-2015)
New Faculty Physician Scientist Translational Research Award, California Institute of Regenerative Medicine (CIRM) (2013 - 2018)
Neuro-Oncology Investigator Award, American Academy of Neurology (2017)
NIH Director's Pioneer Award, NIH (2018-2023)
Boards, Advisory Committees, Professional Organizations
Institutional PI, Pediatric Brain Tumor Consortium (PBTC) (2018 - Present)
Chair, High-grade Glioma Working Group, Pediatric Brain Tumor Consortium (2013 - Present)
Member, Pediatric Brain Tumor Consortium Translational Biology Committee (2012 - Present)
Current Research and Scholarly Interests
Much of brain development occurs after birth. Maturation of complex neural circuitry necessary for high-level cognitive and motor functions occurs throughout childhood and young adulthood. Central to the process of developing or strengthening a functional neural circuit is the generation of new glial cells for neuronal support, synapse formation and myelination. In some brain regions, such as the hippocampus, new neuron production occurs throughout postnatal life and is believed to subserve normal memory function.
The Monje Lab studies the molecular and cellular mechanisms of postnatal neurodevelopment. This includes microenvironmental influences on neural precursor cell fate choice in normal neurodevelopment and in disease states. Areas of emphasis include neuronal instruction of gliogenesis, cellular contributions to the neurogenic and gliogenic signaling microenvironment, molecular determinants of neural precursor cell fate, and the role of neural precursor cells in oncogenesis and repair mechanisms. As a practicing neurologist and Neuro-oncologist, Dr Monje is particularly interested in the roles for neural precursor cell function and dysfunction in the origins of pediatric brain tumors and the consequences of cancer treatment. As a paradigm of pediatric gliogenesis, she has been focusing on brainstem tumors, whose spatial and temporal specificity bespeak an underlying developmental cause.